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  • The migration and growth of cancer cells at sites far from the initial tumour is usually fatal. Metabolic heterogeneity — variable expression of an enzyme in the initial tumour — is identified as an early step in this deadly process.

    • Sanjeethan C. Baksh
    • Lydia W. S. Finley
    News & Views
  • A microfluidic system achieves miniaturization without the need for extra equipment, bringing chip-based devices closer to mainstream commercial reality, with a framework that could be widely applied to diagnostics.

    • Mazher Iqbal Mohammed
    News & Views
  • Two galaxies that are curiously lacking in dark matter — the most abundant matter in the Universe — might have formed when a collision between dwarf galaxies separated ordinary matter from its dark counterpart.

    • Eun-jin Shin
    • Ji-hoon Kim
    News & Views
  • It emerges that high blood sugar deregulates the enzyme TET3 in the eggs of female mice, preventing it from properly modifying sperm-derived DNA when eggs are fertilized. This leads to metabolic defects in adult progeny.

    • Yumiko K. Kawamura
    • Antoine H. F. M. Peters
    News & Views
  • Infusion of cerebrospinal fluid from young mice into old mice restores memory recall in the aged animals by triggering production of the fatty myelin sheath that insulates neurons in the brain.

    • Miriam Zawadzki
    • Maria K. Lehtinen
    News & Views
  • A rare event has been identified in a brief detection of X-rays. Serendipity only pays off when you know what to do with it, and researchers have used the finding to verify a long-standing theory about a class of exploding star.

    • Frederick M. Walter
    News & Views
  • The beating of hair-like structures that enable microorganisms to swim has been replicated in a polymer material that bends and twists with the help of light-sensitive molecular machines.

    • Dhanya Babu
    • Nathalie Katsonis
    News & Views
  • It has long been thought that two enzymes, the kinases CDC7 and CDK2, are both needed to trigger DNA replication in mammalian cells. This view is challenged by evidence that offers a revised view of which kinases are essential.

    • Masato T. Kanemaki
    News & Views
  • Many mysteries remain about how antiviral responses shape the ability of viruses to infect bacteria. The finding that viruses interfere with signalling mediated by molecules called second messengers sheds light on bacterial defences.

    • Urs Jenal
    News & Views
  • Experiments on the mouse brain reveal that neuronal signals from the midbrain to the cortex act as a switch that transforms the dynamics of cortical neuronal activity and, in turn, initiates movement.

    • Oliver M. Gauld
    • Chunyu A. Duan
    News & Views
  • Waste streams of the plastic poly(ethylene terephthalate) that can be recycled into material suitable for food packaging are limited, creating a shortfall of feedstocks. An enzyme has been discovered that widens the feedstock options.

    • Eggo U. Thoden van Velzen
    • Giusy Santomasi
    News & Views
  • In an impressively thorough study, phosphorylation in the core of a transfer RNA molecule has been described for the first time, and the enzymes that add and remove the phosphate group have been characterized.

    • Mark Helm
    • Yuri Motorin
    News & Views
  • Analysis of zebrafish larvae reveals that epithelial cells in their skin undergo tension-driven division without DNA replication. This allows rapid expansion, enabling the cells to cover the fast-growing organism.

    • Aki Stubb
    • Sara A. Wickström
    News & Views
  • Experiments and fieldwork show that teams working together online produce fewer ideas than those collaborating in person — a first step towards answering the question of which modes of communication are generally best for creativity.

    • Emőke-Ágnes Horvát
    • Brian Uzzi
    News & Views
  • Fatty structures called plaques can form in arteries, and are separated from nerves by the artery walls. But this is no barrier to communication — it seems that nerves interact with plaques and immune cells to drive cardiovascular disease.

    • Courtney Clyburn
    • Susan J. Birren
    News & Views